With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
In a 25 mL round bottom flask was added 100 mg (0.22 mmol) of Intermediate 4, 59.8 mg (0.26 mmol) of 1-(4-trifluoromethylphenyl)piperazine, 182 mg (1.32 mmol) of potassium carbonate, 15 mL of acetonitrile,The reaction was carried out at 86[deg.] C. for 16 h. TLC showed that the starting material was completely reacted. Stop the reaction, filter, and concentrate. The crude product was purified by column chromatography on silica gel, eluent: V (ethyl acetate): V (petroleum ether) = 1:3 to give 35.2 mg of a white solid. Yield: 33%.
30459-17-7, The synthetic route of 30459-17-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Yuan Mu; Chen Hong; Ye Bibo; Yang Zonglin; (17 pag.)CN107573302; (2018); A;,
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