With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.,934-98-5
General procedure: To a solution of 6-amino-4-anilinoquinazoline or 4-(1-phenylethyl)quinazoline-4,6-diamine (0.23 mmol) in acetonitrile(5 mL), CDI (0.11 g, 0.69 mmol) was added. The reaction mixture was stirred at room temperature for 8 h when lots of solidproduced. To this suspension, the solution of 2-(4-methylpiperazin-1-yl)ethylamine in 5 mL of acetonitrile was added. Then, the mixture was stirred at room temperature for 2 h, refluxed for another 2 h, cooled to room temperature and concentrated under reduced pressure. The residue was added water (20 mL) and the mixture was extracted with dichloromethane (20 mL 3). The organic layer was combined, washed with brine (20 mL), dried(Na2SO4), concentrated under reduced pressure and purified bychromatography on silica gel (dichloromethane/methanol = 15:1,v/v) to give compounds 4a or 4b as yellow powder. 4.1.60. 1-(2-(4-Methylpiperazin-1-yl)ethyl)-3-(4-((3-(trifluoromethyl)phenyl)amino)quinazolin-6-yl)urea (4a)Yield 45.5percent. Mp: 169.8?170.5 C. 1H NMR (DMSO-d6): d 9.96 (s,1H, N-H), 9.03 (s, 1H, N-H), 8.54 (s, 1H, N-H), 8.46 (d, 1H, Ar-H,J = 2.0 Hz), 8.29 (s, 1H, Ar-H), 8.21 (d, 1H, Ar-H, J = 8.0 Hz), 7.83(dd, 1H, Ar-H, J1 = 2.0 Hz, J2 = 8.8 Hz), 7.74 (d, 1H, Ar-H,J = 8.8 Hz), 7.62 (t, 1H, Ar-H, J = 8.0 Hz), 7.44 (d, 1H, Ar-H,J = 7.6 Hz), 6.35 (t, 1H, Ar-H, J = 5.2 Hz), 3.20?3.29 (m, 4H,2 CH2), 2.41?2.49 (m, 8H, 4 N-CH2), 2.27 (s, 3H, N-CH3). 13CNMR (DMSO-d6): d 157.4, 155.6, 152.5, 145.9, 141.0, 139.2, 130.0,129.5, 128.8, 126.7, 124.7 (d, JC?F = 261 Hz), 126.0, 119.8, 118.4,116.2, 109.3, 57.6, 54.7 (2 CH2), 52.4 (2 CH2), 45.5, 36.9. ESIHRMSm/z: calcd for C23H27F3N7O [M+H]+: 474.2229; found:474.2224.
The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Zuo, Sai-Jie; Zhang, Sai; Mao, Shuai; Xie, Xiao-Xiao; Xiao, Xue; Xin, Min-Hnag; Xuan, Wei; He, Yuan-Yuan; Cao, Yong-Xiao; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 24; 2; (2016); p. 179 – 190;,
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