With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.103-76-4,N-(2-Hydroxyethyl)piperazine,as a common compound, the synthetic route is as follows.
In a three-neck round-bottomed flask, 1-(2-hydroxyethyl)piperazine (3.00 g, 23.05 mmol) was dissolved in 15 mL of water. A solution of benzylchloroformate (3.95 mL, 27.66 mmol) in 15 mL of acetonitrile was added dropwise via isobar cylindrical funnel. In order to maintain the pH around 9, a solution of 4N NaOH was added dropwise via a second isobar cylindrical funnel. The reaction mixture was stirred overnight at RT and then extracted with DCM (2 x 75 mL). The aqueous phase containing the final compound was acidified with 3N HCl and extracted with DCM (3 x 75 mL). Organic extracts were combined, washed with brine (150 mL), dried over anhyd. sodium sulfate and concentrated under vacuum. The crude was purified by flash chromatography (0 to 2% of MeOH in DCM) to afford 18 (5.41g, 90%) as a colorless oil. 1H-NMR (500 MHz, DMSO, delta): 7.37-7.29 (m, 5H, CH arom.), 5.05 (s, 2H, CH2Phi), 4.41 (s, 1H, OH), 3.49 (m, 2H, CH2OH), 3.35 (m, 4H, (CH2)2N(Z)), 2.36 (m, 6H, CH2N, CH2NCH2). 13C-NMR (100.6 MHz, DMSO, delta): 115.04, 137.59, 129.09, 128.49, 128.22, 66.81, 60.83, 59.14, 53.51, 44.16. MS (ESI) m/z 265.00 (M + H)+., 103-76-4
As the paragraph descriping shows that 103-76-4 is playing an increasingly important role.
Reference：
Article; Denoyelle, Severine; Chen, Ting; Chen, Limo; Wang, Yibo; Klosi, Edvin; Halperin, Jose A.; Aktas, Bertal H.; Chorev, Michael; Bioorganic and Medicinal Chemistry Letters; vol. 22; 1; (2012); p. 402 – 409;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics