934-98-5, 2-(4-Methylpiperazin-1-yl)ethanamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a mixture of 2-chloro-N-(3-chlorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)quinazolin-4-amine (Example 1, 39.9 mg, 0.1 mmol) and 2-(4-methylpiperazin-1-yl)ethanamine (143 mg, 1.0mmol) was added EtOH (1 ml). The tube was sealed and heated at 90 00 for 16 h. After cooling to rt, the mixture was filtered through a filter, and submitted for purification to give N4-(3- chlorobenzyl)-6-(3,5-dimethylisoxazol-4-yl)-N2-(2-(4-methylpiperazin- 1 -yl)ethyl)quinazoline-2,4- diamine, 2TFA (28.6 mg, 0.039 mmol, 39.0 percent yield). 1H NMR (400 MHz, DMSO-d6) O 12.81 (5,1H), 10.07 (5, 1H), 9.62 (d, J= 141.1 Hz, 1H), 8.23 (d, J= 1.8 Hz, 1H), 7.82 (dd, J= 8.4, 1.7 Hz,1 H), 7.52 (d, J = 8.5 Hz, 1 H), 7.46 (t, J = 1.9 Hz, 1 H), 7.42 ? 7.27 (m, 3H), 4.83 (d, J = 5.7 Hz,2H), 4.43?2.67 (m, 15H), 2.42 (5, 3H), 2.25 (d, J= 1.4 Hz, 3H). (including 1 salt NH); MS(M+H)= 506., 934-98-5
The synthetic route of 934-98-5 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; STROVEL, Jeffrey William; YOSHIOKA, Makoto; MALONEY, David J.; YANG, Shyh Ming; JADHAV, Ajit; URBAN, Daniel Jason; (334 pag.)WO2017/91661; (2017); A1;,
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