109-01-3, 1-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A) Production of tert-butyl 4-methylpiperazine-1-carboxylate A mixture of 1-methylpiperazine (15 g), triethylamine (22.7 mL) and tetrahydrofuran (300 mL) was cooled to 0C, and di-tert-butyl dicarbonate (22 g) was added with stirring. Thereafter, the reaction system was stirred at room temperature for 3 hr. The reaction mixture was concentrated under reduced pressure, 4M aqueous sodium hydroxide solution (100 mL) was added to the residue, and the mixture was extracted with ethyl acetate (300 mL). The extract was washed with water (200 mL) and dried over anhydrous sodium sulfate. Insoluble material was removed by filtration, and the filtrate was concentrated under reduced pressure. The residue was purified by silica gel column chromatography to give the title compound (25.5 g) as a yellow oil. 1H-NMR(CDCl3) delta 1.40(9H,s), 2.25(3H,s), 2.31(4H,t,J=4.8Hz), 3.40(4H,t,J=4.8Hz).
109-01-3, The synthetic route of 109-01-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Takeda Pharmaceutical Company Limited; EP2540728; (2013); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics