With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
Method 27 (3R, 5S)-3,5-Dimethyl-1-(4-nitrophenyl)piperazine; 1-Fluoro-4-nitrobenzene (lOg, 70. 87mmol) and (2R, 6S)-2, 6-dimethylpiperazine (17g, 148. 83mmol) were heated in acetonitrile (25ml) at 70°C for 2h. The solution was concentrated in vacuo, then the residue was partitioned between DCM and water + sat. sodium hydrogen carbonate. The organic extract was washed with water (4 times), brine, dried and concentrated to give the title compound as a yellow solid which was dried in vac oven overnight at 50°C (16.13g, 97percent). NMR (400MHz) 1.04 (d, 6H), 2.39 (m, 2H), 2.77 (m, 2H), 3.89 (dd, 2H), 7.02 (d, 2H), 8.03 (d, 2H); m/z 236.
21655-48-1, 21655-48-1 cis-2,6-Dimethylpiperazine 6950261, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/75461; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics