1235865-77-6, 2-((1H-Pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5,5-dimethyl-3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methyl)piperazin-1-yl)benzoic acid is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of 2-((lH-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((4′-chloro-5, 5-dimethyl-3.4.5.6-tetrahydro[l,l’-biphenyl]-2-yl)methyl)piperazin-l-yl)benzoic acid (2.0 g) in acetone (20 mL) was treated with p-toluenesulfonicacid monohydrate (1.33 g) and stirred at 20-30 degree Celsius for 4-5h. The resulting slurry was filtered, washed with acetone (10 mL) and the solid was dried under vacuum at 45-50 degree Celsius for 16 h to furnish 2-((lH-pyrrolo [2,3-b] pyridin-5-yl)oxy)-4 -(4-((4′-chloro-5,5-dimethyl- 3.4.5.6-tetrahydro[l,l’-bi phenyl]-2-yl) methyl)piperazin-l-yl) benzoic acid p – toluenesulfonic acid salt. Yield: 86.92 % (2.26 g) HPLC Purity: 97.88% 1H NMR (DMSO-d6): d q.95 (s, 6H), 1.43 (t, J=2.0, 2.4 Hz, 2H), 2.03 (s, 2H), 2.21 (t, br, 2H), 2.29 (s, 6H), 2.77 (m, 2H), 3.09 (m, 2H), 3.29 (m, 2H), 3.61 (m, 2H), 3.74 (m, 2H), 6.42 (m, 2H), 6.76 (dd, J=2.0 Hz, 2H), 7.09 (m, 6H), 7.39 (d, J=8.4 Hz, 2H), 7.50 (t, 5H), 7.78 (d, J=9.2 Hz, 1H), 8.03 (d, J=2.4 Hz, 1H), 11.74 (s, 1H, NH)., 1235865-77-6
The synthetic route of 1235865-77-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; FRESENIUS KABI ONCOLOGY LTD.; GUPTA, Chandan Kumar; DHIMAN, Navdeep; SANGHANI, Sunil; SINGH, Govind; LAHIRI, Saswata; CABRI, Walter; GUPTA, Nitin; (0 pag.)WO2020/3272; (2020); A1;,
Piperazine – Wikipedia
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