197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.
197638-83-8, 1-Boc-4-(4-Formylphenyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 11 terf-Butyl 4-(4-(6-chloro-7-(4-((6-(trifluoromethyl)pyridin-3-yl)methyl)piperazin-1-yl)- 3H-imidazo[4,5-/3]pyridin-2-yl)phenyl)piperazine-1-carboxylate To a mixture of 5-chloro-3-nitro-4-(4-((6-(trifluoromethyl)pyridin-3- yl)methyl)piperazin-1-yl)pyridin-2-amine (0.100 g, 0.24 mmol, 1 eq), EtOH (4.3 mL) and DMF (0.57 mL), te/t-butyl-4-(4-formylphenyl)tetrahydro-1-(2H)pyrazine carboxylate (0.077 g, 0.26 mmol, 1.1 eq) was added followed by a freshly prepared aqueous solution of Na2S2O4 (1 M; 0.72 mL, 0.72 mmol). The reaction mixture was heated at 85C for 24 h, then allowed to cool to room temperature and diluted with DCM and a few drops of aqueous NH3 until complete dissolution was observed. This solution was deposited on two preparative silica TLC plates and eluted with DCM/MeOH (v/v; 94:6). The title compound was obtained after trituration with diethyl ether as an off-white solid (0.042 g, 27%); 1H-NMR (500Mz, DMSO-c/6): 1.43 (s, 9H, C(CH3J3), 2.60-2.67 (m, 4H, piperazine N(CH2J2), 3.27 (t, 4H, J = 5.2 Hz, piperazine N(CH2)2), 3.45-3.51 (m, 4H, piperazine N(CH2J2), 3.66-3.72 (m, 4H, piperazine N(CH2)2), 3.73 (s, 2H, NCH2), 7.06 (d, J = 9.0 Hz, 2H, ArH, C6H4), 7.90 (dd, 1H, pyridine H), 8.03 (d, J = 9.0 Hz, 2H, ArH1 C6H4), 8.04 (s, 1 H, imidazo[4,5-]pyridine 5- H), 8.06-8.11 (m, 1H, pyridine H ), 8.75-8.78 (m, 1H, pyridine H), 13.19 (br s, 1H, imidazo[4,5-ib]pyridine N-H); LC (Method B) – MS (ESI, m/z) 4.93 min – 657/659 [(M+H)+, Cl isotopic pattern]; ESI-HRMS: Found: 657.2675, calculated for C32H37CIF3N8O2 (M+H)+: 657.2671.
197638-83-8, The synthetic route of 197638-83-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; CHROMA THERAPEUTICS LTD.; WO2009/1021; (2008); A1;,
Piperazine – Wikipedia
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