With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.923565-99-5,(R)-1-Cbz-2-methylpiperazine,as a common compound, the synthetic route is as follows.,923565-99-5
To a room temperature solution of (iotaR)-benzyl 2-methylpiperazine-l-carboxylate (1.7 g, 7.2 mmol, 1.0 equiv) and and 3-amino-2-fluorobenzaldehyde (1.0 g, 7.2 mmol, 1.0 equiv) in THF (10 mL) was added NaHB(OAc)3 (3.84 g, 18.1 mmol, 2.5 equiv) as a solid in one portion. After stirring at room temperature for 1.5 h, the reaction was complete, as determined by LCMS. The remaining reducing reagent was quenched by the careful addition of aq. satd. NaHCtheta3, and the mixture was diluted with EtOAc. The layers were separated and the organic layer was washed with aq. satd. NaHCtheta3 and brine, dried over sodium sulfate and concentrated in vacuo to provide (/?)-benzyl 4-(3-amino-2-fluorobenzyl)-2-methylpiperazine- 1-carboxylate (2.8 g, >100% mass recovery). The material was used without further purification. LCMS m/z (APCI) = 358.5 (M+H).
923565-99-5 (R)-1-Cbz-2-methylpiperazine 40424346, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; CYTOKINETICS, INC.; WO2007/70683; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics