70261-82-4,70261-82-4, 4-(4-Methylpiperazin-1-ylmethyl)phenylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The Third Step: Preparation of 1-(4-isothiocyanatobenzyl)-4-methylpiperazine (F652-03) Triethylamine (5.1 mL, 36.6 mmol) was added to a solution of 4-(4-methylpiperazin-1-ylmethyl) phenylamine (F652-02, 3.14 g, 15.3 mmol) in tetrahydrofuran (250 mL), and after cooling by ice, thiophosgene (1.11 mL, 14.6 mmol) was added. After stirring at room temperature overnight, aqueous sodium hydrogencarbonate was added to the mixture. The reaction mixture was extracted with ethyl acetate, and the extract was washed with saturated sodium chloride solution, dried over anhydrous sodium sulfate, filtered to remove sodium sulfate, and the solvent was distilled off under reduced pressure to obtain brownish oil. The brown oil was purified by silica gel column chromatography (chloroform, methanol) to obtain 1-(4-isothiocyanatobenzyl)-4-methylpiperazine (F652-03, brownish oil, 2.64 g, 70%). LC/MS (Method 3): m/z(ESI, POS): 2.48[M+H]+; retention time: 2.87 minutes. 1H-NMR(400MHz, CDCl3)delta 2.29(s, 3H), 2.45(bs, 8H), 3.48(s, 2H), 7.17(d, J=8.4Hz, 2H), 7.31(d, J=8.4Hz, 2H).
The synthetic route of 70261-82-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NIPPON KAYAKU KABUSHIKI KAISHA; EP1857446; (2007); A1;,
Piperazine – Wikipedia
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