With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20327-23-5,1-Cyclopropylpiperazine,as a common compound, the synthetic route is as follows.
A 100 mL round bottom flask was charged with 1.84 g (lOmmol) of compound II, 1.26 g (lOmmol) of compound III-2 and 20 mL of dry THF, and the resulting mixture was stirred under cooling with ice-water bath, After adding 2.48 g (12 mmll) of DCC, stirring was continued at room temperature overnight. TLC shows the completion of the reaction. The reaction mixture was poured into ice water, stirred, extracted with 50 mL of X3 dichloromethane, the combined organic phases were combined, washed with saturated brine, dried over anhydrous sodium sulfate, the solvent was evaporated on a rotary evaporator, The resulting residue was purified by column chromatography to give product 1-2 as a white solid.
20327-23-5, 20327-23-5 1-Cyclopropylpiperazine 4742004, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Zhejiang Pharmaceutical College; Guo Zhanghua; (6 pag.)CN104326974; (2017); B;,
Piperazine – Wikipedia
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