934-98-5,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.934-98-5,2-(4-Methylpiperazin-1-yl)ethanamine,as a common compound, the synthetic route is as follows.
General procedure: The mixture of 6-bromobenzo[d]thiazol-2-amine (2.0 g, 8.73 mmol), carbonyldimidazole (4.24 g, 26.2 mmol) and dried DMF (20 ml) was stirred at room temperature for 8 h, added cyclopropanamine (0.76 g, 13.2 mmol), then stirred at room temperature for another 8 h. The volatile was removed under reduced pressure. Water (30 ml) was added to the residue. The resulting suspension was stirred. After standing, the solid was collected by filtration, dried to produce 8a (1.77 g, 65percent) as white solid. 4.1.1.7 1-(6-Bromobenzo[d]thiazol-2-yl)-3-(2-(4-methylpiperazin-1-yl)ethyl)urea (8g) White solid; Yield 64percent; mp: 97-99 °C; 1H NMR (CDCl3) delta 7.85 (s, 1H, Ar-H), 7.52 (d, J = 8.6 Hz, 1H, Ar-H), 7.47 (d, J = 8.6 Hz, 1H, Ar-H), 3.49 (s, 2H, CH2), 2.78-2.41 (m, 10H, CH2 CH2*5), 2.35 (s, 3H, CH3). MS (ESI, m/z): Calcd for [M+H]+ C15H21BrN5OS: 398, 400, found 398, 400.
934-98-5 2-(4-Methylpiperazin-1-yl)ethanamine 70284, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Xie, Xiao-Xiao; Li, Huan; Wang, Juan; Mao, Shuai; Xin, Min-Hang; Lu, She-Min; Mei, Qi-Bing; Zhang, San-Qi; Bioorganic and Medicinal Chemistry; vol. 23; 19; (2015); p. 6477 – 6485;,
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