109384-27-2, 1-Methylpiperazin-2-one hydrochloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 325 : 4-(4-methoxy-3-(6-(trifluoromethyl)- lH-indazol-4-yl)benzoyl)- 1 – methylpiperazin-2-one [0942] To a vial containing l-methylpiperazin-2-one HC1 (0.172 g, 1.142 mmol) in dioxane (5 mL) was added trimethylaluminum (0.571 mL, 1.142 mmol) in toluene dropwise at room temperature. After stirring for 15 minutes at room temperature, methyl 4-methoxy-3-(6- (trifluoromethyl)-lH-indazol-4-yl)benzoate (0.1 g, 0.285 mmol) was added. The mixture was heated at 110C for 1 hour in a microwave reactor and was subsequently transferred to a round bottom flask. The reaction mixture was quenched with concentrated HC1 and concentrated. The crude residue was purified by preparative HPLC, eluting with 35% acetonitrile (containing 0.035% TFA) in H20 (containing 0.05% TFA) over a period of 5 minutes. The product-containing fractions were combined and the volatiles removed in vacuo to give a TFA salt of the title compound as light brown semisolid (0.024 g, 19%). 1H NMR (400 MHz, DMSO-<) delta ppm 2.86 (s, 3 H), 3.37 (t, J=5.43 Hz, 2 H), 3.70-3.86 (m, 5 H), 4.12 (s, 2 H), 7.29 (d, J=8.59 Hz, 1 H), 7.37 (d, J=1.01 Hz, 1 H), 7.52 (d, J=2.02 Hz, 1 H), 7.61 (dd, J=8.59, 2.27 Hz, 1 H), 7.94 (s, 1 H), 7.99 (d, J=0.76 Hz, 1 H); ESI-MS m/z [M+H]+ calc'd for C2iHi9F3N403, 433.1; found 433.22., 109384-27-2
109384-27-2 1-Methylpiperazin-2-one hydrochloride 17060766, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; CHERUVALLATH, Zacharia; ERICKSON, Philip; FENG, Jun; KOMANDLA, Mallareddy; LAWSON, John David; MCBRIDE, Christopher; MIURA, Joanne; MURPHY, Sean; TANG, Mingnam; TON-NU, Huong-Thu; WO2013/130855; (2013); A1;,
Piperazine – Wikipedia
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