694499-26-8, 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,694499-26-8
To a stirred solution of X (0.120 g, 0.33 mmol), V (0.090 g, 0.33 mmol) added HATU (0.255 g,0.67 mmol) and DIPEA (0.2 mL, 1.08 mmol) in DMF (2 mL). Reaction was allowed to stir at RT for 24 h.After completion of reaction, reaction mixture was diluted with water and extracted with ethyl acetate (15mL x 3). Brine washing was given to the organic layer and dried over anhydrous Na2SO4. Organic layerwas concentrated under vacuum to obtain crude which was purified by using reverse phase HPLC to obtain5 (0.021 g, 10%).LCMS: 613 [M+1]+1HNMR (400 MHz, DMSO) delta10.4 (s, 1H), 10.6 (s, 1H), 8.3 (s, 1H), 8.2 (d, 2H), 8.1 (d, 1H), 7.9 (t, 3H),7.8 (d, 1H), 7.7 (d, 1H), 7.6 (m, 3H), 7.2 (t, 1H), 3.6 (s, 2H), 2.3 (m, 8H), 2.1 (s, 3H).
The synthetic route of 694499-26-8 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Ramachandran, Sreekanth A.; Jadhavar, Pradeep S.; Miglani, Sandeep K.; Singh, Manvendra P.; Kalane, Deepak P.; Agarwal, Anil K.; Sathe, Balaji D.; Mukherjee, Kakoli; Gupta, Ashu; Haldar, Srijan; Raja, Mohd; Singh, Siddhartha; Pham, Son M.; Chakravarty, Sarvajit; Quinn, Kevin; Belmar, Sebastian; Alfaro, Ivan E.; Higgs, Christopher; Bernales, Sebastian; Herrera, Francisco J.; Rai, Roopa; Bioorganic and Medicinal Chemistry Letters; vol. 27; 10; (2017); p. 2153 – 2160;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics