1030377-21-9, (S)-1-Boc-2-(Hydroxymethyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1030377-21-9
A suspension of 1-fluoro-4-nitrobenzene (1.305 g, 9.25 mmol), (S)-tert-butyl 2-(hydroxymethyl)piperazine-1-carboxylate (2.00 g, 9.25 mmol) and potassium carbonate (1.917 g, 13.87 mmol) in anhydrous DMF (10 mL) was heated to 50 C under a nitrogen atmosphere overnight. The reaction mixture was allowed to cool to room temperature, diluted with water (70 mL) and stirred at roomtemperature for 15 minutes. The precipitated solid was isolated by filtration, washed with water (50 mL), sucked dry and freeze-dried overnight to give the title compound as an orange solid (2.13 g, 68%) . ?H NMR (300 MHz, CDC13) 3 8.11 (dt, 2H), 6.78 (dt, 2H), 4.25 (br s, 1H), 3.85-4.04 (m, 2H), 3.61-3.80 (m, 3H), 3.25-3.43 (m, 2H), 3.18(ddd, 1H), 1.49 (s, 9H). LCMS (Method C): RT = 1.39 mm, m/z = 338 [M+H].
As the paragraph descriping shows that 1030377-21-9 is playing an increasingly important role.
Reference：
Patent; ALMAC DISCOVERY LIMITED; HARRISON, Timothy; TREVITT, Graham; HEWITT, Peter Robin; O’DOWD, Colin Roderick; BURKAMP, Frank; WILKINSON, Andrew John; SHEPHERD, Steven D.; MIEL, Hugues; WO2015/92431; (2015); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics