With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.170911-92-9,tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
c (6 g, 21.63 mmol), triethylamine (3.28 g, 32.45 mmol) were added to 100 mL of CH 2 Cl 2 under ice-cooling, and then 3-chloro-benzoyl chloride (4.54 g, 25.96 mmol) was gradually added dropwise. After being transferred to room temperature, stirring for 2 hours;After the reaction was completed, it was quenched by adding 50 mL of water, and then 50 mL of CH2Cl2 solvent was added.After washing with water (50 mL × 3), the organic phase was dried over anhydrous magnesium sulfate,Evaporation to dry d (7.60 g); yield: 84.47%,, 170911-92-9
As the paragraph descriping shows that 170911-92-9 is playing an increasingly important role.
Reference：
Patent; Zhejiang University; Zhengzhou University; Sun Yi; Liu Hongmin; Xu Tiantian; Li Yanan; Yu Bin; Ma Qisheng; Hou Tingjun; Pan Peichen; Xiong Xiufang; (37 pag.)CN110156729; (2019); A;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics