78818-15-2, Benzyl 3-oxopiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
78818-15-2, A mixture of 1 ,1-dimethylethyl 4-[(4-iodophenyl)oxy]-1-piperidinecarboxylate (D1 ) (10.9 g), 4-benzyloxycarbonylpiperazin-2-one (commercially available for example from Fluorochem) (7.6 g), tripotassium phosphate (6.79 g), Lambda/./V-dimethylethylenediamine (0.29 ml) and copper (I) iodide (257 mg) in dioxane (200 ml) was heated under nitrogen to 100 0C for 24 h. The mixture was allowed to cool to room temperature and partitioned between water and EtOAc. The aqueous solution was extracted with more EtOAc and the combined organic solutions were washed with brine, dried and concentrated. The residue was dissolved in DCM and purified by chromatography on Biotage (400 g) eluting with EtOAc-cyclohexane (2:3 to 1 :1 ) to give the title compound (7.36 g) LCMS RT = 3.45 min.
As the paragraph descriping shows that 78818-15-2 is playing an increasingly important role.
Reference：
Patent; GLAXO GROUP LIMITED; WO2007/9741; (2007); A1;,
Piperazine – Wikipedia
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