4318-42-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4318-42-7,1-Isopropylpiperazine,as a common compound, the synthetic route is as follows.
Step 1 (1H-Indol-6-yl)-(4-isopropyl-piperazin-1-yl)-methanone A mixture of 1 g (6 mmol) indole-6-carboxylic acid (commercially available), 0.96 g (0.7 mmol) 1-(2-propyl)-piperazine (commercially available), 2.39 g (7 mmol) TBTU and 4 g (31 mmol) DIPEA in 30 ml THF was stirred for 1 h at room temperature. After evaporation of all volatiles Na2CO3 (10percent aq.) and ethyl acetate was added. The mixture was extracted with ethyl acetate and the combined organic fractions were washed with NaCl (sat. aq.), dried with Na2SO4 and evaporated to dryness. The residue was purified by flash column chromatography on silica eluding with a mixture formed from DCM, MeOH and NH3 aq. to yield after evaporation of the combined product fractions 1.64 g (97percent) of the title compound as light yellow solid. MS (m/e): 272.5 (MH+).
As the paragraph descriping shows that 4318-42-7 is playing an increasingly important role.
Reference：
Patent; Nettekoven, Matthias; Roche, Olivier; US2008/32976; (2008); A1;,
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