With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.259808-67-8,1-Boc-3,3-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
6-(4-Fluorophenyl)-8-( 1 -methylcyclopropyl)imidazo[ 1 ,2-b]pyridazine-2- carboxylic acid (150 mg, 0.48 mmol) was dissolved in DMF (4.5 mL) and HATU (238 mg, 0.63 mmol), tert-butyl 3,3-dimethylpiperazine-1-carboxylate (113.6 mg, 0.53 mmol) and DIPEA (249 mg, 336 .iL, 1.93 mmol) were added. The solution was stirred at r. t. for 3h and then aqueous NH4C1 was added and the aqueous phase was extracted twice with EtOAc. The combined organic layers were washed with iN HC1 aqueous, saturated aqueous NaHCO3 and brine, dried over anhydrous Mg504, filtered and the filtrate evaporated under reduced pressure affording the title compound (245 mg, quantitative) as a yellow solid which was used in the subsequent step without further purification. LC-MS: mlz = 508.17 (M+Hj., 259808-67-8
259808-67-8 1-Boc-3,3-Dimethylpiperazine 22710387, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; VERTEX PHARMACEUTICALS INCORPORATED; FARMER, Luc J.; FOURNIER, Pierre-Andre; LESSARD, Stephanie; LIU, Bingcan; ST-ONGE, Miguel; STURINO, Claudio; SZYCHOWSKI, Janek; YANNOPOULOS, Constantin; WO2015/48245; (2015); A1;,
Piperazine – Wikipedia
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