39539-66-7, 4-Methylpiperazine-1-carbonyl chloride is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
EXAMPLE 1 [1-methyl-4-(N-pyrrolidinocarbonyl)piperazine] In 50 ml of toluene was dissolved 8.1 g (0.05 mole) of 1-methyl-4-chlorocarbonylpiperazine at room temperature and a solution of 10.7 g (0.15 mole) of pyrrolidine in 50 ml of toluene was dropped to the above solution at 0 C. over a period of 30 minutes. The mixture was refluxed for 1 hour to complete the reaction. The reaction mixture was cooled, and the precipitated yellow crystal (pyrrolidine hydrochloride) was removed by filtration. The filtrate was dried with anhydrous sodium sulfate and toluene as the solvent was removed by distillation under reduced pressure to obtain crude 1-methyl-4-(pyrrolidinocarbonyl)piperazine as the distillation residue. The crude product was purified by distillation under reduced pressure to obtain 6.6 g of a pure product having a boiling point of 109.5 to 110.0 C. at 0.5-0.6 mm Hg obs. The yield was 66.9%. The elementary analysis values are as follows: Found: C=61.07%, H=9.89%, N=21.20% Anal. Calcd for C10 H19 N3 O: C=60.87%, H=9.73%, N=21.30%
39539-66-7, The synthetic route of 39539-66-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Mitsuitoatsu Chemicals Inc.; US4420481; (1983); A;,
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