70261-81-3,70261-81-3, 1-Methyl-4-(4-nitrobenzyl)piperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
The Second Step: Preparation of 4-(4-methylpiperazin-1-ylmethyl)phenylamine (F652-02) 1-methyl-4-(4-nitrobenzyl)-piperazine (F652-01, 4.67 g, 19.9 mmol), methanol (100 mL), zinc powder (6.5 g, 99.3 mmol) and ammonium chloride (4.3 g, 79.5 mmol) were placed in a reaction vessel and heated for 2 hours under reflux. After returning to room temperature, the reaction mixture was filtered through Celite. The solvent of the filtrate was distilled off under reduced pressure to obtain a solid. Diethyl ether was added to the solid, and insoluble components were removed by filtration. 4-(4-methylpiperazin-1-ylmethyl)phenylamine (F652-02, white solid, 3.16 g, 77%) was obtained by removing the solvent of the filtrate by distillation. LC/MS (Method 6): m/z(ESI, POS): 206[M+H]+; retention time: 1.15 minutes. 1H-NMR(400MHz, DMSO-d6)delta 2.12(s, 3H), 2.29(bs, 8H), 3.23(s, 2H), 4.93(s, 2H), 6.49(d, J=8.4Hz, 2H), 6.89(d, J=8.4Hz, 2H).
The synthetic route of 70261-81-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NIPPON KAYAKU KABUSHIKI KAISHA; EP1857446; (2007); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics