With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.485841-52-9,(S)-1,2-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
To a solution of (R)-3-cyclohexyl-2, 3-dihydropyrrolo [1,2, 3-de] -1, 4-benzoxazine-6- carboxylic acid (120 mg, 0.421 mmol) and (S)-1, 2-dimethylpiperazine (62 mg, 0.547 mmol) in N,N-dimethylformamide (3.0 mi) was added 1- (3-dimethylaminopropyl)-3- ethylcarbodiimide (97 mg, 0.505 mmol) and 1-hydroxy benzotriazole (68 mg, 0.505 mmol). The mixture was stirred at room temperature for 18 h, then partitioned between dichloromethane and water. The aqueous layer was extracted with dichloromethane, and combined organic layers were washed with brine, dried over Na2SO4 and concentrated. The residue was purified by flash chromatography eluting with 0-20% (v/v) methanol in ethyl acetate to afford the title compound as the free base. Hydrochloride salt formation was achieved by the addition of hydrogen chloride (2 M solution in diethyl ether; 0.5 mi) to a solution of the free base in diethyl ether (2 ml) and ethanol (1 ml). The solvent was removed in vacuo and the precipitate was dried to afford title compound (1: 1 hydrochloride salt) as a solid (84 mg, 0.20 mmol). ‘H NMR (400MHz, CD30D) 81. 00-1. 35 (5H, m), 1.39 (3H, d, J 4. 8), 1.58 (1H, d, J 12.0), 1.60-1. 70 (1H, m), 1.70-1. 82 (3H, m), 1.82-1. 90 (1H, m), 2.96 (3H, s), 3.20- 3.70 (5H, m), 4.20-4. 30 (2H, m), 4.40-4. 70 (2H, m), 4.71 (1H, d, J 10.0), 6.67 (1H, d, J 8.2), 7.08 (1H, t, J8. 2), 7.21 (1H, d, J 8.2), 7.74 (1H, s); EsIMS : m/z = 382.1 [M+H] +, 268.1
485841-52-9, The synthetic route of 485841-52-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; AKZO NOBEL N.V.; WO2005/58327; (2005); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics