With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.159532-59-9,(S)-1-(tert-Butoxycarbonyl)piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
Lithium aluminium hydride (1M in THF, 19.5 ml) was added to a solution of (2S)-1- (tert-butoxycarbonyl) piperazine-2-carboxylic acid (1.5 g) in THF (20 ml) at 0C, then the reaction was warmed to room temperature and heated at 60C for 16 hours. The reaction was cooled to 0C and quenched by sequential addition of water (0.75 ml), sodium hydroxide (2N, 0.75 ml) and then water (1.5 ml). The resulting slurry was filtered and concentrated in vacuo and the residue purified by chromatography using DCM to 20% 7N ammonia in methanol in DCM to [(2S)-L-METHYLPIPERAZIN-2-YL] METIZANOL as a white solid (454 mg, 53%) ; NMR spectrum (DMSO-d6) 1. 83 (m, 1H), 1. 98 (dt, 1H), 2.14 (s, 3H), 2.31 (dd, 1H), 2.56 (m, 2H), 2. 68 (m, 1H), 2. 84 (dd, 1H), 3.23 (dd, 1H), 3.52 (dd, 1H).
159532-59-9, As the paragraph descriping shows that 159532-59-9 is playing an increasingly important role.
Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/26152; (2005); A1;,
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