With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13889-98-0,1-Acetylpiperazine,as a common compound, the synthetic route is as follows.
INTERMEDIATE 19(S)-tert-Butyl 1 -|”2-(4-acetylpiperazin- 1 -yl)-8-methylquinolin-3-yllethylcarbamateIntermediate 9 (150 mg, 0.47 mmol), 1-acetylpiperazine (300 mg, 2.34 mmol), DIPEA (0.42 mL, 2.34 mmol) and NMP (3 mL) were combined in a sealed tube and heated to 1400C for 48 h. After cooling, the reaction mixture was dissolved in a 1 :1 mixture of EtOAc and Et2O (100 mL) and washed with saturated brine (3 x 25 mL). The organic layer was dried (MgSO4) and concentrated in vacuo. Purification by column chromatography (SiO2, 0-100% EtOAc in isohexane) afforded the title compound (151 mg, 78%) as a white solid. LCMS (ES+) 413 (M+H)+.
13889-98-0, As the paragraph descriping shows that 13889-98-0 is playing an increasingly important role.
Reference：
Patent; UCB PHARMA S.A.; ALLEN, Daniel, Rees; BROWN, Julien, Alistair; BUeRLI, Roland; HAUGHAN, Alan, Findlay; LANGHAM, Barry, John; MATTEUCCI, Mizio; OWENS, Andrew, Pate; RAPHY, Gilles; SHARPE, Andrew; WO2010/133836; (2010); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics