With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.163765-44-4,(R)-1-Boc-3-Methylpiperazine,as a common compound, the synthetic route is as follows.
The compound (R) -3- methyl-piperazine-1-carboxylate (500mg, 2.5mmol) and triethylamine (700mg,6.3mmol) in methylene Dichloromethane (10 mL), and the conditions under 0 C, to this solution was addeddropwise methanesulfonyl chloride (0.39mL, 4.99mmol), stirred at rt for 8h, add Water (10mL × 3), dried overanhydrous Na 2 SO 4 organic phase was dried, the solvent was removed concentrate was subjected to columnchromatography (eluent: Petroleum ether / EtOAc (v / v) = 2/1), to give 444mg white solid: (R) -3- methyl-4-(methylsulfonyl) piperazine-1-carboxylate, yield: 63% ., 163765-44-4
163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Guangdong East Sunshine Pharmaceutical Co., Ltd; Zhang, Ying jun; Liu, Bing; Yu, Tian Zhu; Zhang, Xiang Yu; (348 pag.)CN105399698; (2016); A;,
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