216144-45-5, 4-(4-Methylpiperazin-1-yl)benzylamine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Stage 3: 1′-[4-(4-methylpiperazin-1-yl)benzyl]-2’H-spiro[cyclopentane-1,3′-imidazo[2,1-b]quinazoline]-2′,5′(1’H)-dione hydrochloride[4-(4-methylpiperazin-1-yl)benzyl]amine (950 mg) is added to methyl 1-(2-chloro-4-oxoquinazolin-3(4H)-yl)cyclopentane carboxylate (520 mg) in anhydrous THF (2 mL) placed in a ?Biotage? reaction tube. The reaction tube is sealed with a cap, stirred at ambient temperature for 1 hour then placed in a ?Biotage? micro-wave and heated under magnetic stirring at 100 C. for 1 hour. The mixture is concentrated under reduced pressure at 40 C. Purification by flash chromatography on silica gel (eluent: dichloromethane/methanol 95:5) produces the expected compound in the form of the free base. The corresponding hydrochloride salt is formed by adding a 1N HCl solution in ethyl ether to the solution of the free base in ethyl acetate. The precipitate obtained is filtered and dried in order to produce the expected hydrochloride compound (235 mg, 27% yield from Stage 2).MS/LC: calculated MM=443.5; m/z=444.3 (MH+)NMR (1H, 400 MHz, CDCl3): delta2.07 (s, 2H), 2.19 (s, 6H), 2.90 (s, 3H), 3.61 (m, 6H), 4.06 (m, 2H), 5.55 (s, 2H), 7.27 (m, 2H), 7.46 (m, 1H), 7.77 (m, 3H), 8.24 (AB, 1H), 8.68 (AB, 1H), 13.35 (s, 1H).
216144-45-5, 216144-45-5 4-(4-Methylpiperazin-1-yl)benzylamine 2776493, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; SOCIETE DE CONSEILS DE RECHERCHES ET D’APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.); US2010/144714; (2010); A1;,
Piperazine – Wikipedia
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