With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.115619-01-7,4-(4-Ethylpiperazin-1-yl)phenylamine,as a common compound, the synthetic route is as follows.
A mixture of 5 (0.11g, 0.56mmol), DIPEA (0.10ml, 0.56mmol) and acetonitrile (3ml) was mixed with the 86 (0.10g, 0.56mmol) and then stirred at room temperature for overnight. The reaction was quenched by saturated NaHCO3 (aq.) and the mixture was extracted by ethyl acetate (30ml x 3). The residue was purified by flash column over silica gel (dichloromethane: methanol = 15: 1, Rf = 0.18) to afford 90 (0.06g, 30.80%) as a brown solid. 1H-NMR (300MHz, CDCl3): delta 1.15 (t, J= 7.2 Hz, 3H), 2.51 (q, J= 7.2 Hz, 2H), 2.64 (s, 4H), 3.01 (d, J= 7.2 Hz, 3H), 3.22 (t, J= 5.4 Hz, 4H), 5.30 (br, 1H), 5.74 (br, 1H), 6.88-6.94 (m, 2H), 7.11 (s, 1H), 7.35 (d, J= 9.0 Hz, 1H), 7.37-7.48 (s, 1H)., 115619-01-7
The synthetic route of 115619-01-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; TAIPEI MEDICAL UNIVERSITY; YEN, Yun; LIOU, Jing-Ping; CHEN, Chun-Han; (70 pag.)WO2017/15400; (2017); A1;,
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