With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34334-28-6,4-(4-Methylpiperazin-1-yl)benzonitrile,as a common compound, the synthetic route is as follows.
Under nitrogen, 4- (4-methylpiperazin-1-yl) benzonitrile (500 mg, 2.48 mmol) and tetraisopropyl titanate (1.25 mL, 4.22 mmol) were added to ether (10 mL). Ethylmagnesium bromide (1.82 mL, 5.46 mmol, 3M ether solution) was added dropwise to the reaction system at 78 C.The reaction was stirred at room temperature for 1.5 hours.Boron trifluoride ether (0.94 mL, 7.45 mmol) was then dropped into the reaction system, and the reaction system was stirred at room temperature for 1 hour.The reaction solution was quenched with water, the reaction solution was extracted with ethyl acetate, the organic phase was separated, and the residue was purified by silica gel column chromatography (dichloromethane / methanol = 95/5) to obtain 1- (4- (4-methylpiperazine). Azin-1-yl) phenyl) cyclopropylamine (7A, 180 mg, yield: 31%) was a yellow oil., 34334-28-6
As the paragraph descriping shows that 34334-28-6 is playing an increasingly important role.
Reference：
Patent; Shanghai Dinuo Pharmaceutical Technology Co., Ltd.; Zhao Zhiming; (42 pag.)CN110467629; (2019); A;,
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