With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.
75336-86-6, Synthesis of (3R)-3-methyl-1-(phenyl(3-(trifluoromethyl)phenyl)-methyl)piperazine To a solution of (R)-(-)-2-methylpiperazine (2.2 g, 22 mmol) in CH3CN (20 mL) was added 1-(chloro(phenyl)methyl)-3-(trifluoromethyl)benzene (2.0 g, 7.4 mmol) and heated to 100° C. for 12 h and concentrated under vacuum. The residue was dissolved in CH2Cl2 (150 mL) and washed with 1N NaOH (150 mL). The organic layer was dried with K2CO3 or Na2SO4, filtered, and concentrated. The crude product was purified by ISCO using 0-20percent 2N NH3/MeOH solution in CH2Cl2 to give the title compound (2.00 g, 81percent yield) as oil. MS (ESI, pos. ion) m/z: 335.1 (M+1).
As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.
Reference：
Patent; Hitchcock, Stephen; Amegadzie, Albert; Qian, Wenyuan; Xia, Xiaoyang; Harried, Scott S.; US2008/4289; (2008); A1;,
Piperazine – Wikipedia
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