With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.181955-79-3,1,4-Di-Boc-piperazine-2-carboxylic acid,as a common compound, the synthetic route is as follows.,181955-79-3
The resulting 1,4-di-tert-butoxycarbonylpiperazine-2-carboxylic acid (13-2) (500 mg, 1.5 mmol)Was dissolved in dry THF (10 mL)Under nitrogen protection,After borane tetrahydrofuran (4.5 mL, 4.5 mmol) was added dropwise,Heated to 40 for 2 hours,Cold to 0 ,The reaction was quenched by the dropwise addition of methanol and the reaction was concentrated to dryness to give 470 mg of 1,4-di-tert-butoxycarbonyl-2-hydroxymethylene-piperazine (13-3) in a yield of 98%
The synthetic route of 181955-79-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Fujian Jinle Pharmaceutical Technology Co., Ltd.; Zhou Zhongxiang; Xing Yuanyuan; Chen Yingzhong; Deng Chengjun; Deng Honggui; Xue Wanhua; Zhang Shuzu; Chen Weipeng; Li Fang; (27 pag.)CN107174584; (2017); A;,
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