With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.109-01-3,1-Methylpiperazine,as a common compound, the synthetic route is as follows.
The 1-(2-hydroxyethyl)-4-methylpiperazine used as a starting material was prepared as follows: A mixture of 2-bromoethanol (2.36 g), N-methylpiperazine (1.26 g), potassium carbonate (5.0 g) and ethanol (150 ml) was stirred and heated to reflux for 18 hours. The mixture was cooled to ambient temperature and filtered. The filtrate was evaporated and the residue was triturated under a mixture of methylene chloride and acetone. The resultant mixture was filtered and the filtrate was evaporated to give the required starting material as an oil (0.87 g); NMR Spectrum: (CDCl3) 2.18 (s, 3H), 2.3-2.7 (br m, 81), 2.56 (t, 2H), 3.61 (t, 2H)., 109-01-3
As the paragraph descriping shows that 109-01-3 is playing an increasingly important role.
Reference：
Patent; Hennequin, Laurent Francois Andre; Crawley, Graham Charles; McKerrecher, Darren; Ple, Patrick; Poyser, Jeffrey Philip; Lambert, Christine Marie Paul; US2003/225111; (2003); A1;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics