163765-44-4, (R)-1-Boc-3-Methylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of (R) -tert-butyl 3-methylpiperazine-1-carboxylate (200 mg, 1.00mmol) , 2-cyclopropylacetic acid (120 mg, 1.20 mmol) , EDCI (287mg, 1.50 mmol) and HOAT (340 mg, 2.50 mmol) in DCM (20 mL) was stirred at 0 , and DIPEA (0.70 mL, 4.00mmol) was added dropwise. After the addition, the mixture was stirred at rt for16 h and washed with water (10 mL × 2) . The organiclayer was dried over anhydrous Na2SO4 and concentrated.The residue was purified by silica gel chromatography eluted with Petroleumether/EtOAc (v/v) 2/1 to give (R) -tert-butyl 4-(2-cyclopropylacetyl) -3-methylpiperazine-1-carboxylate as colorless oil (260mg, 92) . 1H NMR (400 MHz, CDCl3): delta ppm 3.85-4.14 (m, 3H) , 3.31-3.55 (m, 1H) , 2.80-2.97 (m, 3H) , 2.30-2.33,2.20-2.23 (m, m, 0.5H, 1.5H) , 1.46 (s, 9H) , 1.15-1.24 (m, 3H) , 1.03-1.07 (m,1H) , 0.55-0.57 (m, 2H) , 0.15-0.18 (m, 2H) ., 163765-44-4
163765-44-4 (R)-1-Boc-3-Methylpiperazine 2756811, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
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