4318-42-7, 1-Isopropylpiperazine is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step 2 [3-(1-Benzyl-piperidin-2-yl)-1H-indol-6-yl]-(4-isopropyl-piperazin-1-yl)-methanone A mixture of 1.25 g (4 mmol) 3-(1-benzyl-piperidin-2-yl)-1H-indole-6-carboxylic acid methyl ester and 0.2 g (4.8 mmol) LiOH.H2O in 40 mL water and 40 mL methanol was heated to reflux for 20 h. After 4 h additional 0.56 g LiOH.H2O and 30 mL water was added. After evaporation of the methanol the mixture was adjusted to pH=2 and evaporated to dryness. 25 mL DMF was added and together with 1.4 g (4 mmol) TBTU, 2.8 g (22 mmol) DIPEA and 0.55 g (4 mmol) 1-(2-propyl)-piperazine stirred at room temperature for 3 h. Isolute was added and after evaporation purified by column chromatography on silica eluding with a gradient formed from DCM/methanol/NH3 aq. The product fractions were evaporated to yield 1.14 g (71percent) of the title compound as light brown solid. MS (m/e): 445.3 (MH+)., 4318-42-7
The synthetic route of 4318-42-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Nettekoven, Matthias; Roche, Olivier; US2008/32976; (2008); A1;,
Piperazine – Wikipedia
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