With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.252990-05-9,Methyl (R)-1-Boc-piperazine-2-carboxylate,as a common compound, the synthetic route is as follows.
Step 1 To a stirred solution of 1-(tert-butyl) 2-methyl (R)-piperazine-1,2-dicarboxylate (2.0 g. 8.2 mmol) in CH2Cl2 was added naphthalen-1-ylboronic acid (9.8 mmol, 1.2 equiv) and Cu(OAc)2 (500 mg) and stirring continued for 48 h under a balloon of air. The solution was washed with H2O, dried over Na2SO4 and evaporated. Column chromatography (20% EtOAc-hexanes) gave 1-(tert-butyl) 2-methyl (R)-4-(naphthalen-1-yl)piperazine-1,2-dicarboxylate (402 mg, 13% yield) as an oil., 252990-05-9
252990-05-9 Methyl (R)-1-Boc-piperazine-2-carboxylate 7009916, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; Omeros Corporation; Cutshall, Neil S.; Gage, Jennifer Lynn; Gruswitz, Franz A.; Khalaf, Juhienah; Little, Thomas L.; Metz, Markus; Nguyen, Jeremiah H.; Nollert von Specht, Peter Kurt; Tsoung, Jennifer; Cicirelli, Michael; Goldstein, Sara Rebecca; Keshipeddy, Santosh Kumar; Kwon, Do Yeon; Lemus, Robert Huerta; Vaddela, Sudheer Babu; (638 pag.)US2019/367452; (2019); A1;,
Piperazine – Wikipedia
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