With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.182618-86-6,1-Boc-4-(4-Nitrophenyl)piperazine,as a common compound, the synthetic route is as follows.
To the reaction flask was added compound 40 (17.57 g, 63.39 mmol)Soluble in methanol,Add 1.7 g of Pd / C,Catalytic hydrogenation at room temperature,TLC tracking, to be completely complete,Diatomaceous earth filtration,The solvent was removed by distillation under reduced pressure,To obtain a crude solid,And then beaten with ether to get pink powder,Drying to give 12.31 g of compound 7-11,Yield: 73.8%., 182618-86-6
The synthetic route of 182618-86-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Zhang Yinsheng; Gao Yong; Ren Jing; Wang Qinglin; Wang Zhao; (67 pag.)CN106905245; (2017); A;,
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