With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1152367-80-0,(S)-1,3-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
Intermediate 11CSV 2,4-dimethylpiperazi – 1 -carbonyl chlorideTo a solution of triphosgene (1.04 g, 3.5 mmol) in DCM (20 mL) under nitrogen was added pyridine (2.3 g, 28.0 mmol) drop-wise at 0C followed by addition of (S)-l,3- dimethylpiperazine (800 mg, 7.0 mmol) in DCM (30 mL), the reaction mixture was warmed to RT and stirred overnight as monitored by TLC (Rf= 0.9, PE: EtOAc = 1 : 1). The mixture was concentrated to give Intermediate 1 1 (3 g, crude) which was used without purification.
1152367-80-0, As the paragraph descriping shows that 1152367-80-0 is playing an increasingly important role.
Reference：
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; LI, David, Yunzhi; WANG, Jiabing; YANG, Zhenfan; ZENG, Qingbei; ZHANG, Xiaolin; WO2014/135876; (2014); A1;,
Piperazine – Wikipedia
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