314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step A: (S)-tert-butyl 3-(hydroxymethyl)-4- (2- (3-nitrophenyl)-2-oxoethyl)piperazine- 1- carboxylate: 2-Bromo-1-(3-nitrophenyl)ethanone (1.Olg, 4.14 mmol) was dissolved in THF (2OmL) and added (S)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (1.074 g, 4.97 mmol) followed by Hunig?s base (1.45 mL, 8.28 mmol) then stirred at room temperature overnight. The reaction was poured into water and extracted with EtOAc (2x). The organic layer was separated, dried over Na2SO4, filtered and concentrated. The product was purified bychromatography through a 120g ISCO Redi-sep column eluting with 0-70% ethyl acetate/hexane to yield the title compound., 314741-40-7
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Reference：
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; DEJESUS, Reynalda, Keh; FRIE, Jessica, L.; PIO, Barbara; TANG, Haifeng; WALSH, Shawn, P.; WO2014/99633; (2014); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics