With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.120737-59-9,tert-Butyl 3-methylpiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
EXAMPLE 106; Synthesis of 1,1-dimethylethyl 4-(2-{[(5-{[(5-bromo-2- methyIphenyl)amino]carbonyl}-lH-imidazol-4-yl)carbonyl]amino}-lH-benzimidazol-6-yl)-3-methylpiperazine-l-carboxylate; Synthesis of terf-Butyl 4-(3,4-dinitrophenyl)-3-methylpiperazine-l-carboxylate; [00350] 4-Fluoro-l,2-dinitrobenzene (0.93g, 5.0 mmol, commercially available from Oakwood Products) and rert-butyl 3-methylpiperazine-l-carboxylate (l.Og, 5.0 mmol) were dissolved in 3 mL of DMA, and 3 mL of diisopropylethylamine was added. The mixture was stirred at 50 0C overnight, and then cooled to room temperature, separated between ethyl acetate and water. The combined organic were washed with water, brine, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The residue was separated by silica gel column (20percent to 40percent ethyl acetate in hexanes) to give 1.0 g of 4-(3,4- dinitrophenyl)-3-methylpiperazine-l-carboxylate. 1H-NMR (400 MHz, CDCl3): delta 8.05 (d, 2H), 6.84 (m, 2H), 3.90-4.10 (m, 3H), 3.05-3.60 (m, 4H), 1.50 (s, 9H), 1.10 (s, 3H). MS (EI): 367 (MH+).
120737-59-9, The synthetic route of 120737-59-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; EXELIXIS, INC.; WO2008/42282; (2008); A2;,
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