With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5271-27-2,1-Methyl-3-phenylpiperazine,as a common compound, the synthetic route is as follows.
5271-27-2, General procedure: A mixture of 3 (2.91 g, 10 mmol), 4 (1.76 g, 10 mmol)and KF (18 mmol) were heated at 120-130 °C in DMF (30mL) for 16 – 18 h. At the end of this period, the reactionmixture was cooled to room temperature and diluted withwater (30 mL). The separated solid was filtered, washed anddried to obtain crude 6a-i. The obtained crude product wasthen purified by recrystallization using ethanol.
5271-27-2 1-Methyl-3-phenylpiperazine 2760009, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Darsi, S.S. Praveen Kumar; Kumar, K. Shiva; Devi, B. Rama; Naidu; Dubey; Letters in Organic Chemistry; vol. 11; 8; (2014); p. 551 – 555;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics