With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.75336-86-6,(R)-2-Methylpiperazine,as a common compound, the synthetic route is as follows.,75336-86-6
EXAMPLE 16; Example 16A. 1.1.1 -trifluoro-2-f4-( ((2R)-2-methyl-4-r2-f trifluoromethvDphenyl’lpiperazin- 1 – yl 1 sulfonvOphenyl’lpropan-sigma-ol; Step 16A; A mixture of (R)-2-methyl-piperazine (300 mg, 2.99 mmol), 2-bromo benzotrifluoride (612 mg, 2.72 mmol), tris(dibenzylidineacetone)dipalldium (0) (24.72 mg, 0.027 mmol), rac-2,2′-bis(diphenylphosphino)-l,l’-binaphtyl (51.06 mg, 0.082 mmol) and sodium tert- butoxide (326.77 mg, 3.4 mmol) were charged to a microwave vial. Toluene (3.0 mL) was introduced under nitrogen atmosphere and the reaction mixture was irradiated at 1 1O0C for 30 minutes. Reaction was complete as determined by TLC. The reaction was repeated at (R)-2- methyl-piperazine (1.0 g, 9.98 mmol). Reaction mixtures were combined, diluted with dichloromethane, washed with water, saturated brine then dried over Na2SO4 and concentrated. The crude product was purified via flash column chromatography to yield (R)-3-methyI-l -(2- trifluoromethyl-phenyO-piperazine as yellow oil (1.23 g, 39.6percent yield). IH NMR (400 MHz, CHLOROFORM-D) delta ppm 1.07 (d, J=6.32 Hz, 3 H) 2.41 – 2.51 (m, 1 H) 2.74 – 2.84 (m, 1 H)
As the paragraph descriping shows that 75336-86-6 is playing an increasingly important role.
Reference：
Patent; WYETH; WO2007/92435; (2007); A2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics