With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.21655-48-1,cis-2,6-Dimethylpiperazine,as a common compound, the synthetic route is as follows.
Under an argon atmosphere, 3,4-difluoronitrobenzene(1.0 g, 6.29 mmol) in acetonitrile (15 mL)To the solution was added cis-3,5-dimethylpiperazine (861 mg, 7.55 mmol), N, N-diisopropylethylamine (2.19 mL,12.6 mmol), and the mixture was stirred at 80 ° C. for 2 hours.Water was added to the reaction solution, and the mixture was extracted with chloroform.The chloroform layer was washed with saturated brine and saturated brine,After drying over anhydrous magnesium sulfate, filtration,The solvent was distilled off. The resulting residue was purified by silica gel column chromatography (NH column, chloroform / methanol) to give the title compound (1.42 g, 89percent)., 21655-48-1
The synthetic route of 21655-48-1 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Yakult Honsha Corporation; Abe, Atsuhiro; Mae, Satoyuki; Yamazaki, Ryuta; Sawaguchi, Yuichi; Sugimoto, Takuya; Sasai, Toshio; Nishiyama, Hiroyuki; Nagaoka, Masato; Matsuzaki, Ken; Kurita, Akinobu; Matsui, Makoto; Shingeyama, Takahide; (208 pag.)JP6378918; (2018); B2;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics