314741-40-7, (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,314741-40-7
Step A: tert-Butyl (3S)-4-[2-( 4-cyano-3 -methoxyphenyl )-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate: A Pyrex vessel was charged with magnetic stirringbar, (0.350 g, 2.00 mmol) of2-methoxy-4-(oxiran-2-yl) benzonitrile, (0.457 g, 2.20 mmol) oftert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate, and 6 mL ofEtOH. Then it was introduced in the microwave reactor and irradiated at 150 C for 3 hr. Then the mixture wascooled to room temperature and the solvent was evaporated and the resulting residue waspurified by column chromatography (silica gel, 1- 20% dichloromethane/MeOH) which affordedthe title compound as a mixture of two diastereomers (1 :1). LC/MS: (IE, mlz) [(M + 1)- t-But =336.1.
314741-40-7 (S)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate 24820294, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; MERCK SHARP & DOHME CORP.; PASTERNAK, Alexander; BLIZZARD, Timothy; CHOBANIAN, Harry; DE JESUS, Reynalda; DING, Fa-Xiang; DONG, Shuzhi; GUDE, Candido; KIM, Dooseop; TANG, Haifeng; WALSH, Shawn; PIO, Barbara; JIANG, Jinlong; WO2013/28474; (2013); A1;,
Piperazine – Wikipedia
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