With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.300543-56-0,(R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine,as a common compound, the synthetic route is as follows.
Example 5; Preparation of Compound (II) & its hydrochloride salt; Compound III (obtained in example 2) was taken in toluene (300 ml). To this, 2-chloroethanol (23.29 g) and triethylamine (72.12 ml) were added and then heated to 1 10-1 15C for 3h. After cooling the reaction mass to 75-80C, the remaining 15.52 g of 2-chloroethanol was added. The temperature of the reaction mixture was further raised to 1 10-1 15C and maintained at this temperature for 4h. The progress of reaction was montiored by HPLC. After the completion, it was allowed to cool to 25- 30C and followed by the addition of water (150 ml) and stirred for 10 min. After separating the organic layer, it was washed with water (75ml) and then 1 12.5 ml of water was added to the organic layer. The pH of the reaction mixture was adjusted to 1.0-2.0 using cone. HC1 (~28 ml). After stirring, the aqueous layer was separated. To the aqueous layer, dichloromethane (225 ml) was added and adjusted the pH to 9.5- 10.0 using liquid ammonia. The organic layer was separated, washed with water (150 ml) and concentrated to yield an oily mass of title compound. This oily mass was taken in acetone (750 ml) and heated at 40-45C to get clear solution. The reaction mixture was cooled to 25-30C and cone. HC1 (45.8 ml) was added. It was allowed to stir for 12h at 25-30C. The solid thus obtained was washed with acetone (75 ml) and dried under vacuum to yield 68.61 g hydrochloride salt of title compound with 49.4% yield (with respect to compound (V)).
300543-56-0, The synthetic route of 300543-56-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; JUBILANT LIFE SCIENCES LIMITED; BISWAS, Sujay; DUBEY, Shailendra, Kumar; MANGLA, Amit; MASAND, Mukesh; VIR, Dharam; WO2012/101475; (2012); A1;,
Piperazine – Wikipedia
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