With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.78818-15-2,Benzyl 3-oxopiperazine-1-carboxylate,as a common compound, the synthetic route is as follows.
78818-15-2, (2R, 3R, 4R)-2- [ (1R)-1- [3,5-Bis (trifluoromethyl) phenyl] [ETHOXY]-3- (4-] fluorophenyl) tetrahydro-2H-pyran-4-methyl methanesulfonate (WO 00/56727-A1 ; 2.32 g, 4.26 mmol) was added to a solution of [4-BENZYLOXYCARBONYLPIPERAZIN-2-ONE] (1.30 g, 5.54 mmol) and sodium hydride (60% dispersion in mineral oil, 170 mg, 4.26 mmol) in N, [N-DIMETHYLFORMAMIDE] (25 mL) and the mixture was stirred at [50 C] for 16 hours. Further sodium hydride (60% dispersion in mineral oil, 85.2 mg, 2.13 mmol) was added the mixture was stirred at 50 [C] for 1.5 hours. The mixture was cooled and the solvent was evaporated under reduced pressure. Water (50 mL) was added and the mixture was extracted with ethyl acetate [(3] x 100 mL). The combined organic fractions were washed with brine (150 mL), dried (MgSO4) and the solvent was evaporated under reduced pressure. The residue was purified by flash column chromatography on silica gel, eluting with hexane/EtOAc (70: 30 increasing to 0: 100) to give the title compound (2.06 g, [71%).] m/z (ES+) 683 [(M+1),] 425 [(M+1-CIOHSF6O).]
As the paragraph descriping shows that 78818-15-2 is playing an increasingly important role.
Reference：
Patent; MERCK SHARP & DOHME LIMITED; WO2004/9573; (2004); A1;,
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