With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216144-45-5,4-(4-Methylpiperazin-1-yl)benzylamine,as a common compound, the synthetic route is as follows.
To a solution of 6b (1eq.) in isopropanol the amine 11 (2.5 eq.) and N,N-diisopropylethylamine(4 eq.) were added. The reaction mixture was irradiated with microwaves for 10min at 160 C. The reaction mixture was evaporated under reduced pressure. Theyellow residue was diluted with EtOAc and washed with water. The organic phasewas washed with ammonium chloride, dried over Na2SO4 andfinally evaporated under reduced pressure. The crude mixture was purified byflash chromatography on silica gel (CH2Cl2:MeOH 98:2) togive the desired compound 9b as awhite solid (67%). 1H NMR (400 MHz, CDCl3): delta(ppm)3.31(t, J=8, 4H); 4.07 (t, J=8, 4H), 4.55(s, 2H); 4.91-4.85 (2m, 2H); 5.47 (t,J=8, 1H); 6.88 (d, J=8, 2H); 7.19-7-33 (m, 6H), 7.89 (s,1H); 8.30 (s,1H). 13CNMR (CDCl3): delta(ppm) 44.98; 48.83; 53.59; 59.22; 64.99; 116.20;128.53; 128.82; 132.82; 134.80; 136.51; 150.24; 155.27. MS: m/z 483 [M+H]+.Anal. Calcd. For C24H25Cl2N7: C,59.75; H, 5.22; N, 20.32; found: C, 59.55; H, 5.12; N, 20.21, 216144-45-5
The synthetic route of 216144-45-5 has been constantly updated, and we look forward to future research findings.
Reference：
Article; Radi, Marco; Bernardo, Vincenzo; Vignaroli, Giulia; Brai, Annalaura; Biava, Mariangela; Schenone, Silvia; Botta, Maurizio; Tetrahedron Letters; vol. 54; 38; (2013); p. 5204 – 5206;,
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