With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: Arylpiperazines (1.2 equiv) and potassium carbonate (4.0equiv) were added to a solution of 1 (1 equiv) in acetonitrile(CH3CN, 20 mL). The reaction mixture was heated to 85 Cand stirred for 12 h. Afterward the mixture was cooled toroom temperature. The reaction mixture was filtered, and thefiltrate was concentrated in vacuo. The residue was extractedwith ethyl acetate (60 mL) and water (20 mL). After dryingthe organic layer with anhydrous Na2SO4and evaporatingthe solvent under reduced pressure, a solid was appeared.The solid was recyrstallized from ethanol to obtain intermediates2.
30459-17-7, As the paragraph descriping shows that 30459-17-7 is playing an increasingly important role.
Reference：
Article; Chen, Hong; Jia, Huixia; Qian, Yuna; Shen, Jianliang; Yu, Yuzhong; Zhang, Haibo; Zhao, Shanchao; Pharmacological Reports; (2020);,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics