With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.30459-17-7,1-(4-Trifluoromethylphenyl)piperazine,as a common compound, the synthetic route is as follows.
General procedure: To a stirred solution of 2-(3-bromopropyl) isoindoline-1,3-dione (1.0 g, 1 mmol) in N,N-dimethyl formamide DMF(5 mL), N-phenyl piperazine derivatives (1 mmol) andK2CO3 (1.1 g, 3 mmol) were added at room temperature.The reaction mixture was stirred at room temperature for 24h. The resulting solution was poured into ice cold water,which was then extracted with ethyl acetate. Ethyl acetatewas separated, dried over Na2SO4, and concentrated undervacuum to afford corresponding compounds 8a-g.
30459-17-7, 30459-17-7 1-(4-Trifluoromethylphenyl)piperazine 121718, apiperazines compound, is more and more widely used in various fields.
Reference：
Article; Venkatesh, Ramineni; Kasaboina, Suresh; Janardhan, Sridhara; Jain, Nishant; Bantu, Rajashaker; Nagarapu, Lingaiah; Medicinal Chemistry Research; vol. 25; 9; (2016); p. 2070 – 2081;,
Piperazine – Wikipedia
Piperazines – an overview | ScienceDirect Topics