With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.112257-24-6,1-Boc-3-Carbamoylpiperazine,as a common compound, the synthetic route is as follows.,112257-24-6
A mixture of (S) -5- (1- ( (tert-butoxycarbonyl)amino) ethyl) -2- (3- (cyclopropylmethoxy) -4- (difluoromethoxy) phenyl)oxazole-4-carboxylic acid (300 mg, 0.64 mmol) , tert-butyl3-carbamoylpiperazine-1-carboxylate (153 mg, 0.64 mmol) , EDCI (250 mg, 1.3mmol) and HOAT (174 mg, 1.3 mmol) in DCM (25 mL) was stirred at 0 , and DIPEA(0.33 mL, 1.93 mmol) was added dropwise. After the addition, the mixture wasstirred at rt for 5 h and washed with water (10 mL × 3) . The organic layer wasdried over anhydrous Na2SO4 and concentrated. The residuewas purified by silica gel chromatography eluted with Petroleum ether/EtOAc(v/v) 2/3 to give the title compound as a white solid (220 mg, 50) . 1H NMR (400 MHz, CDCl3): delta ppm 7.52-7.61 (m, 2H) , 7.26 (d, J 8.3 Hz, 1H) , 6.72 (t, JF-H 75.0 Hz, 1H) , 5.42-5.49 (m, 1H) , 5.15-5.23 (m, 1H) , 4.01 (d, J 6.9 Hz,2H) , 3.71-3.79 (m, 1H) , 3.17-3.24 (m, 2H) , 1.59-1.64 (m, 3H) , 1.51 (s, 9H), 1.42 (m, 9H) , 1.30-1.35 (m, 1H) , 0.69-0.73 (m, 2H) , 0.42-0.45 (m, 2H) and MS-ESI: m/z 680.30 [M+H] +.
112257-24-6 1-Boc-3-Carbamoylpiperazine 11042527, apiperazines compound, is more and more widely used in various fields.
Reference：
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperazine – Wikipedia
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