129779-30-2, (3R,5S)-rel-tert-Butyl 3,5-dimethylpiperazine-1-carboxylate is a piperazines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of /er/-butyl (3/^,5.V)-3,5-dimethylpiperazine- 1 -carboxylate (compound Id, CAS: 129779-30-2, PharmaBlock, Catalog: PB125871, 100 mg, 467 pmol) and K2C03 (129 mg, 933 pmol) in MeCN (5 mL) was added l-bromo-4-(bromo methyl) benzene (compound le, CAS: 589-15-1, Accela ChemBio, Catalog: SY001367, 117 mg, 467 pmol). The resultant mixture was heated to 80 C for 14 hrs, then cooled to room temperature. The reaction mixture was filtered and the filter cake was washed with EA (10 mL). The combined filtrate was concentrated in vacuo and purified by flash chromatography (silica gel, 12 g, 10% to 50% EtOAc in PE). The purified intermediate was dissolved in DCM (2 mL) and TFA (0.5 mL) was added. The reaction mixture was stirred at room temperature for 3 hrs, then concentrated to afford a crude compound If, MS: calc?d 283 and 285 [(M+H)+], measured 283 and 285 [(M+H)+], 129779-30-2
The synthetic route of 129779-30-2 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DEY, Fabian; QIU, Zongxing; ZHU, Wei; ZOU, Ge; (55 pag.)WO2020/20800; (2020); A1;,
Piperazine – Wikipedia
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