With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216144-45-5,4-(4-Methylpiperazin-1-yl)benzylamine,as a common compound, the synthetic route is as follows.
EXAMPLE 80 N-[4-(4-methyl-piperazin-1-yl)-phenylmethyl]-3-(biphenyl-2-carbonylamino)-benzoic acid amide Prepared analogously to Example 34 from 3-(biphenyl-2-carbonylamino)-benzoic acid, 4-(4-methyl-piperazin-1-yl)-benzylamine, TBTU and N-ethyldiisopropylamine in dimethylformamide. Rf value:0.20 (silica gel; dichloromethane/ethanol=9:1) C32H32N402 (504.63) Mass spectrum:(M-H)-=503 (M+H)+=505 (M+Na)+=527
216144-45-5, As the paragraph descriping shows that 216144-45-5 is playing an increasingly important role.
Reference：
Patent; Priepke, Henning; Hauel, Norbert; Thomas, Leo; Mark, Michael; Dahmann, Georg; US2002/32238; (2002); A1;,
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